Carbidopa, Levodopa And Entacapone has 22 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 11 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Mao Inhibitors, Apomorphine, Bitolterol. Patients taking Carbidopa, Levodopa And Entacapone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 22
- Contraindicated
- 1
- Major
- 11
- Moderate
- 8
Contraindicated (1)
- Carbidopa, Levodopa And Entacapone + Mao Inhibitors— Increased adrenergic tone risk. Use is contraindicated in patients receiving nonselective MAO inhibitors.
Major (11)
- Carbidopa, Levodopa And Entacapone + Apomorphine— May result in increased heart rates, possibly arrhythmias, and excessive changes in blood pressure. Metabolized by COMT.
- Carbidopa, Levodopa And Entacapone + Bitolterol— May result in increased heart rates, possibly arrhythmias, and excessive changes in blood pressure. Metabolized by COMT.
- Carbidopa, Levodopa And Entacapone + Carbidopa— May result in increased heart rates, possibly arrhythmias, and excessive changes in blood pressure. Metabolized by COMT.
- Carbidopa, Levodopa And Entacapone + Dobutamine— May result in increased heart rates, possibly arrhythmias, and excessive changes in blood pressure. Metabolized by COMT.
- Carbidopa, Levodopa And Entacapone + Dopamine Agonists— May result in increased heart rates, possibly arrhythmias, and excessive changes in blood pressure. Metabolized by COMT.
- Carbidopa, Levodopa And Entacapone + Epinephrine— May result in increased heart rates, possibly arrhythmias, and excessive changes in blood pressure. Metabolized by COMT.
- Carbidopa, Levodopa And Entacapone + Isoetherine— May result in increased heart rates, possibly arrhythmias, and excessive changes in blood pressure. Metabolized by COMT.
- Carbidopa, Levodopa And Entacapone + Isoproterenol— May result in increased heart rates, possibly arrhythmias, and excessive changes in blood pressure. Metabolized by COMT.
- Carbidopa, Levodopa And Entacapone + Norepinephrine— May result in increased heart rates, possibly arrhythmias, and excessive changes in blood pressure. Metabolized by COMT.
- Carbidopa, Levodopa And Entacapone + Papaverine— Beneficial effects of levodopa in Parkinson's disease have been reported to be reversed by papaverine.
- Carbidopa, Levodopa And Entacapone + Phenytoin— Beneficial effects of levodopa may be reversed by phenytoin. Dose increase may be necessary and careful monitoring requi…
Moderate (8)
- Carbidopa, Levodopa And Entacapone + Acidifying Agents— Symptomatic postural hypotension may occur; dose adjustment of antihypertensive drug may be required.
- Carbidopa, Levodopa And Entacapone + Butyrophenones— Dopamine D2 receptor antagonists may reduce therapeutic effects of levodopa.
- Carbidopa, Levodopa And Entacapone + Coumadin— Dose adjustment may be required; monitor INR when initiating carbidopa, levodopa and entacapone in patients on coumadin.
- Carbidopa, Levodopa And Entacapone + Iron Salts— May reduce efficacy of carbidopa, levodopa and entacapone tablets.
- Carbidopa, Levodopa And Entacapone + Isoniazid— May reduce therapeutic effects of levodopa; dose increase may be necessary.
- Carbidopa, Levodopa And Entacapone + Metoclopramide— Dopamine D2 receptor antagonist may reduce therapeutic effects of levodopa.
- Carbidopa, Levodopa And Entacapone + Phenothiazines— Dopamine D2 receptor antagonists may reduce therapeutic effects of levodopa.
- Carbidopa, Levodopa And Entacapone + Risperidone— Dopamine D2 receptor antagonist may reduce therapeutic effects of levodopa.