Glycopyrrolate has 13 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Potassium Chloride, Amantadine, Anti-Arrhythmics. Patients taking Glycopyrrolate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 13
- Contraindicated
- 1
- Major
- 6
- Moderate
- 6
Contraindicated (1)
- Glycopyrrolate + Potassium Chloride— Solid dosage forms of potassium chloride are contraindicated due to arrested or delayed passage through GI tract with gl…
Major (6)
- Glycopyrrolate + Amantadine— Potential for additive anticholinergic interaction resulting in increased anticholinergic adverse reactions.
- Glycopyrrolate + Anti-Arrhythmics— Potential for additive anticholinergic interaction resulting in increased anticholinergic adverse reactions.
- Glycopyrrolate + Antispasmodics— Potential for additive anticholinergic interaction resulting in increased anticholinergic adverse reactions. Concomitant…
- Glycopyrrolate + Digoxin— Slow dissolution digoxin tablets may have increased serum levels and enhanced action with glycopyrrolate. Monitor for in…
- Glycopyrrolate + Haloperidol— Haloperidol serum levels may be decreased, resulting in worsening of schizophrenic symptoms and tardive dyskinesia devel…
- Glycopyrrolate + Iobenguane I-123— Potential for additive anticholinergic interaction resulting in increased anticholinergic adverse reactions.
Moderate (6)
- Glycopyrrolate + Atenolol— Atenolol bioavailability may be increased with glycopyrrolate coadministration. A reduction in atenolol dose may be need…
- Glycopyrrolate + Digoxin Tablets— Glycopyrrolate can increase digoxin serum levels. Monitor patients and consider alternative dosage forms.
- Glycopyrrolate + Levodopa— Levodopa's therapeutic effect may be reduced with glycopyrrolate administration. Consider increasing levodopa dose.
- Glycopyrrolate + Metformin— Metformin plasma levels may be elevated with glycopyrrolate, increasing pharmacologic and toxic effects. Monitor respons…
- Glycopyrrolate + Phenothiazines— Concurrent use may intensify antimuscarinic effects and increase anticholinergic side effects.
- Glycopyrrolate + Potassium Chloride In A Wax Matrix— Concomitant administration with glycopyrrolate may increase severity of potassium chloride-induced gastrointestinal lesi…