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Does Glycopyrrolate Interact with Metformin?

The glycopyrrolate oral-solution label states that coadministration may increase metformin concentrations and toxic effects. It advises monitoring response and possible clinician-directed dose adjustment.

Label evidence and limitations

Named-drug label evidence. The product and route matter. This source comparison does not independently validate CDI’s moderate category.

Product scope: Glycopyrrolate oral solution, not every glycopyrrolate formulation.

Read the DailyMed label: These highlights do not include all the information needed to use GLYCOPYRROLATE oral solution safely and effectively. See full prescribing information for GLYCOPYRROLATE oral solution. GLYCOPYRROLATE oral solution Initial U.S. Approval: 1961
Section: 7 Drug Interactions — Metformin. Compared version 15, label date 2026-05-14. The linked label may be updated after this comparison.

This comparison uses the label identifier saved with the CDI record. The compared version may be newer than the original extraction.

AI-assisted source comparison dated 2026-10-16. This is a comparison of label text, not independent clinical review or an individual safety assessment. CDI's stored severity category is not an FDA-assigned rating. Confirm your exact medicines and formulations with your pharmacist or prescriber before changing treatment.

Stored CDI classification: Moderate
Management: Confirm exact products with your pharmacist
Data Source: Product label via NLM DailyMed

What To Tell Your Doctor or Pharmacist

If you are taking Glycopyrrolate and your doctor is considering prescribing Metformin (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Never stop or change either medication without first consulting your healthcare provider

💊 Glycopyrrolate(Glycate)+💊 Metformin(Kazano)

Severity & Interaction Details

🟡

Stored CDI classification: moderate

Named-drug label evidence

The product and route matter. This source comparison does not independently validate CDI’s moderate category.

Stored CDI scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

—

Source

NLP:glycopyrrolate

How to interpret this source comparison

The product and route matter. This source comparison does not independently validate CDI’s moderate category.

About Glycopyrrolate and Metformin

You may recognize them by the brand names Glycate and Kazano. Metformin additionally carries an FDA boxed warning, the FDA's strongest safety alert.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: NLP:glycopyrrolate

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How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.