Stavudine has 6 known drug interactions based on U.S. FDA drug labeling data. Of these, 4 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Abacavir , Lamivudine And Zidovudine, Cladribine, Lamivudine And Zidovudine. Patients taking Stavudine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 6
- Contraindicated
- 4
- Major
- 1
- Moderate
- 1
Contraindicated (4)
- Stavudine + Abacavir , Lamivudine And Zidovudine— Concomitant use with zidovudine should be avoided due to demonstrated in vitro antagonistic relationship.
- Stavudine + Cladribine— Compound requiring intracellular phosphorylation could interfere with cladribine's phosphorylation and activity. Avoid c…
- Stavudine + Lamivudine And Zidovudine— Concomitant use should be avoided due to demonstrated antagonistic relationship with zidovudine in vitro.
- Stavudine + Zidovudine— Concomitant use should be avoided due to demonstrated antagonistic relationship in vitro.
Major (1)
- Stavudine + Hydroxyurea— Fatal and nonfatal pancreatitis, hepatotoxicity with hepatic failure, and severe peripheral neuropathy reported in HIV p…
Moderate (1)
- Stavudine + Ribavirin— Ribavirin may antagonize antiviral activity and inhibit phosphorylation, potentially decreasing antiretroviral activity.…