Does Lamivudine And Zidovudine Interact with Stavudine?
CDI records a contraindicated classification for Lamivudine And Zidovudine and Stavudine. The stored summary is: Concomitant use should be avoided due to demonstrated antagonistic relationship with zidovudine in vitro. The mechanism involves antagonistic relationship with zidovudine. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Lamivudine And Zidovudine Class
- Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Antagonistic relationship with zidovudine
What To Tell Your Doctor or Pharmacist
If you are taking Lamivudine And Zidovudine and your doctor is considering prescribing Stavudine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider