Does Stavudine Interact with Ribavirin?
CDI records a moderate classification for Stavudine and Ribavirin. The stored summary is: Ribavirin may antagonize antiviral activity and inhibit phosphorylation, potentially decreasing antiretroviral activity. Use with caution despite no pharmacokinetic interaction observed in some studies. The mechanism involves inhibition of phosphorylation; potential antagonism of cell culture antiviral activity. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Ribavirin Class
- Nucleoside Analog Antiviral
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Inhibition of phosphorylation; potential antagonism of cell culture antiviral activity
What To Tell Your Doctor or Pharmacist
If you are taking Stavudine and your doctor is considering prescribing Ribavirin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider