Levodopa has 43 known drug interactions based on U.S. FDA drug labeling data. Of these, 10 are contraindicated combinations that should be avoided entirely. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amisulpride, Ferrous Fumarate, Folate, Ferrous Fumarate, Folic Acid. Patients taking Levodopa should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 43
- Contraindicated
- 10
- Major
- 6
- Moderate
- 27
Contraindicated (10)
- Levodopa + Amisulpride— Reciprocal antagonism of effects occurs between dopamine agonists and AMISULPRIDE. Avoid using levodopa with AMISULPRIDE…
- Levodopa + Ferrous Fumarate, Folate— Pyridoxine antagonizes the action of levodopa. Not recommended and should not be given to patients receiving levodopa.
- Levodopa + Ferrous Fumarate, Folic Acid— Action of levodopa is antagonized by pyridoxine. Not recommended and should not be given together.
- Levodopa + Folate, Multivitamin— Action of levodopa is antagonized by pyridoxine in this product. Not recommended and should not be given together.
- Levodopa + Folic Acid— Not recommended and should not be given together as folic acid antagonizes the action of levodopa.
- Levodopa + Mao Inhibitors— Nonselective MAO inhibitors are contraindicated with levodopa. Discontinue at least two weeks prior to initiating levodo…
- Levodopa + Metoclopramide— Dopaminergic agent with opposing effects on dopamine. Avoid concomitant use to prevent exacerbation of parkinsonian symp…
- Levodopa + Metoclopramide Hydrochloride— Dopaminergic agent with opposing effects on dopamine; potential exacerbation of parkinsonian symptoms. Avoid concomitant…
- Levodopa + Multivitamin— Pyridoxine in the multivitamin antagonizes the action of levodopa. Not recommended and should not be given together.
- Levodopa + Pyridoxine Hydrochloride— Pyridoxine antagonizes the action of levodopa. Should not be given concurrently unless levodopa is in a preparation cont…
Major (6)
- Levodopa + Bupropion— Dopaminergic drug; concomitant use with bupropion can cause CNS toxicity; use with caution.
- Levodopa + Bupropion Hcl Er— CNS toxicity can occur when used concomitantly with bupropion.
- Levodopa + Bupropion Hydrobromide— CNS toxicity can occur when used concomitantly with bupropion. Use with caution.
- Levodopa + Bupropion Hydrochloride— Dopaminergic drug. CNS toxicity can occur when used concomitantly with bupropion.
- Levodopa + Olanzapine And Samidorphan L-Malate— Concomitant use is not recommended due to dopamine antagonism by olanzapine potentially reducing levodopa efficacy.
- Levodopa + Sapropterin Dihydrochloride— Sapropterin may increase tyrosine availability, a levodopa precursor. Neurologic events reported post-marketing in patie…
Moderate (27)
- Levodopa + Ascorbic Acid, Vitamin A Palmitate, Cholecalciferol, Thiamine Hydrochloride, Riboflavin-5 Phosphate Sodium, Pyridoxine Hydrochloride, Niacinamide, Dexpanthenol, Alpha-Tocopherol Acetate, Vitamin K1, Folic Acid, Biotin, Cyanocobalamin— Pyridoxine may increase metabolism of levodopa, decreasing blood levels and efficacy.
- Levodopa + Butyrophenones— Butyrophenones (dopamine D2 receptor antagonists) may reduce the effectiveness of levodopa. Monitor patients for worseni…
- Levodopa + Carbidopa— Carbidopa may potentiate the dopaminergic side effects of levodopa and may cause or exacerbate preexisting dyskinesia.
- Levodopa + Glycopyrrolate— Levodopa's therapeutic effect may be reduced with glycopyrrolate administration. Consider increasing levodopa dose.
- Levodopa + Glycopyrrolate Oral Solution— Levodopa's therapeutic effect may be reduced with glycopyrrolate administration. Consider increasing levodopa dose.
- Levodopa + Haloperidol Decanoate— Haloperidol may antagonize the effects of levodopa and reduce its therapeutic effectiveness.
- Levodopa + Haloperidol Lactate— Haloperidol may impair antiparkinson effects of levodopa; extrapyramidal symptoms may occur if both discontinued simulta…
- Levodopa + Iron Salts— Iron salts can form chelates with levodopa and reduce its bioavailability. Monitor patients for reduced levodopa effecti…
- Levodopa + Isoniazid— Isoniazid may reduce the effectiveness of levodopa. Monitor patients for worsening Parkinson's symptoms.
- Levodopa + Macimorelin Acetate— May transiently elevate growth hormone concentrations and impact accuracy of MACRILEN diagnostic test. Avoid concomitant…
- Levodopa + Multiple Vitamins Injection— Pyridoxine increases levodopa metabolism, decreasing blood levels and efficacy.
- Levodopa + Naltrexone Hydrochloride And Bupropion Hydrochloride— Dopaminergic drug that can cause CNS toxicity when used concomitantly with CONTRAVE. Dose with caution.
- Levodopa + Olanzapine— Olanzapine may antagonize levodopa effects.
- Levodopa + Olanzapine And Fuoxetine— Olanzapine and fluoxetine may antagonize levodopa effects.
- Levodopa + Olanzapine Pamoate— Olanzapine may antagonize the effects of levodopa.
- Levodopa + Paliperidone— Paliperidone may antagonize the effect of levodopa and other dopamine agonists.
- Levodopa + Paliperidone Palmitate— Paliperidone may antagonize the effect of levodopa. Monitor and manage patient as clinically appropriate.
- Levodopa + Phenothiazines— Phenothiazines (dopamine D2 receptor antagonists) may reduce the effectiveness of levodopa. Monitor patients for worseni…
- Levodopa + Quetiapine— Quetiapine may antagonize the effects of levodopa. Caution advised with concomitant use.
- Levodopa + Quetiapine Fumarate— Quetiapine may antagonize the effects of levodopa.
- Levodopa + Risperidone— Risperidone may antagonize the effects of levodopa.
- Levodopa + Sepiapterin— Sepiapterin may increase tyrosine availability, a precursor of levodopa. Monitor patients for changes in neurologic stat…
- Levodopa + Tolcapone— When combined with tolcapone and desipramine, frequency of adverse events increased slightly. Caution advised due to add…
- Levodopa + Trihexyphenidyl Hydrochloride— Concomitant administration may increase drug-induced involuntary movements; dose of either drug may need reduction.
- Levodopa + Ziprasidone— Ziprasidone may antagonize the effects of levodopa.
- Levodopa + Ziprasidone Hcl— Ziprasidone may antagonize the effects of levodopa, potentially reducing its therapeutic efficacy.
- Levodopa + Ziprasidone Mesylate— Ziprasidone may antagonize the effects of levodopa.