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Does Levodopa Interact with Ferrous Fumarate Folate?

Levodopa and Ferrous Fumarate Folate have a contraindicated drug interaction according to U.S. FDA drug labeling data. Pyridoxine antagonizes the action of levodopa. Not recommended and should not be given to patients receiving levodopa. The mechanism involves pyridoxine antagonism of levodopa action. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Levodopa Class
Aromatic Amino Acid
Ferrous Fumarate Folate Class
Vitamin C
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Levodopa and Ferrous Fumarate Folate occurs because pyridoxine antagonism of levodopa action. Clinically, this means pyridoxine antagonizes the action of levodopa. not recommended and should not be given to patients receiving levodopa. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Levodopa and your doctor is considering prescribing Ferrous Fumarate Folate (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Levodopa(Inbrija)+💊 Ferrous Fumarate Folate(Finazol)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Aromatic Amino Acid
Drug B class
Vitamin C
Source
NLP:ferrous fumarate, folate

What this means in plain English

Pyridoxine antagonizes the action of levodopa. Not recommended and should not be given to patients receiving levodopa.

What the FDA label says

"Pyridoxine antagonism of levodopa action"

📖 Source: NLP:ferrous fumarate, folate

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.