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Amiloride

30 interactions on record

Amiloride has 30 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 16 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Potassium Chloride, Potassium Citrate, Amlodipine And Benazepril Hydrochloride. Patients taking Amiloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 30
Contraindicated: 2
Major: 16
Moderate: 12

Contraindicated (2)

Amiloride + Potassium Chloride— Concomitant use can produce severe hyperkalemia. Contraindicated.
Amiloride + Potassium Citrate— Concomitant administration can produce severe hyperkalemia and should be avoided.

Major (16)

Amiloride + Amlodipine And Benazepril Hydrochloride— Potassium-sparing diuretic can increase the risk of hyperkalemia. Frequent monitoring of serum potassium is recommended …
Amiloride + Captopril And Hydrochlorothiazide— May cause significant increase in serum potassium. Should only be given for documented hypokalemia and with caution due …
Amiloride + Enalapril— Potassium-sparing diuretic may lead to significant increases in serum potassium. Avoid in heart failure patients.
Amiloride + Enalapril Maleate— Potassium-sparing diuretic may lead to significant increases in serum potassium when used with enalapril.
Amiloride + Fosinopril— Potassium-sparing diuretic that can increase risk of hyperkalemia when used with fosinopril. Requires caution and freque…
Amiloride + Lisinopril— Potassium-sparing diuretic can increase risk of hyperkalemia when used with lisinopril; requires frequent monitoring of …
Amiloride + Lisinopril And Hydrochlorothiazide Tablets— Potassium-sparing diuretic may lead to significant hyperkalemia when used with lisinopril which attenuates potassium los…
Amiloride + Losartan Potassium— Concomitant use may lead to increases in serum potassium, which can be serious.
Amiloride + Olmesartan Medoxomil— Potassium-sparing diuretic may lead to increases in serum potassium. Monitoring of serum potassium is advisable.
Amiloride + Perindopril Erbumine— Risk of hyperkalemia. Perindopril may increase serum potassium by decreasing aldosterone production.
Amiloride + Ramipril— Potassium-sparing diuretic increases risk of hyperkalemia. Frequent monitoring of serum potassium recommended if concomi…
Amiloride + Sacubitril And Valsartan— May lead to increased serum potassium levels. Monitor potassium levels during concomitant use.
Amiloride + Sodium Chloride, Sodium Lactate, Potassium Chloride, Calcium Chloride And Dextrose Monohydrate— Increased risk of severe and potentially fatal hyperkalemia when potassium chloride solution is administered.
Amiloride + Trandolapril— Potassium-sparing diuretic increases risk of hyperkalemia when used with trandolapril; requires caution and appropriate …
Amiloride + Valsartan— Potassium-sparing diuretic may lead to increases in serum potassium and in heart failure patients, increases in serum cr…
Amiloride + Valsartan And Hydrochlorothiazide— Potassium-sparing diuretic may lead to increases in serum potassium and in heart failure patients to increases in serum …

Moderate (12)

Amiloride + Amlodipine And Valsartan— Potassium-sparing diuretic that may increase serum potassium when combined with valsartan. Monitor serum potassium level…
Amiloride + Benazepril Hydrochloride— Increased risk of hyperkalemia. Monitor serum potassium frequently during concomitant use.
Amiloride + Enalapril Maleate And Hydrochlorothiazide— Potassium-sparing diuretic may lead to significant increases in serum potassium when used concomitantly with enalapril; …
Amiloride + Enalapril Maleate Oral Solution— Potassium-sparing diuretic may lead to significant increases in serum potassium when combined with enalapril. Avoid in h…
Amiloride + Enalaprilat— Potassium-sparing diuretic may lead to significant increases in serum potassium when used concomitantly with enalaprilat…
Amiloride + Fosinopril Sodium— Potassium-sparing diuretic that can increase risk of hyperkalemia when combined with fosinopril. Serum potassium should …
Amiloride + Fosinopril Sodium And Hydrochlorothiazide— Potassium-sparing diuretic may increase risk of hyperkalemia when used with fosinopril sodium and hydrochlorothiazide; r…
Amiloride + Leucine, Phenylalanine, Lysine, Methionine, Isoleucine, Valine, Histidine, Threonine, Tryptophan, Alanine, Glycine, Arginine, Proline, Serine, Tyrosine, Dibasic Potassium Phosphate, Magnesium Chloride, Sodium Chloride, Calcium Chloride, Dextrose— Potassium-sparing diuretic may increase risk of hyperkalemia when used with CLINIMIX E due to its potassium content; adm…
Amiloride + Metformin Hydrochloride— Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for commo…
Amiloride + Moexipril Hydrochloride— Potassium-sparing diuretic may increase risk of hyperkalemia when used concomitantly with moexipril. Requires caution an…
Amiloride + Quinapril— Potassium-sparing diuretic may increase serum potassium when used with quinapril. Use with caution and monitor serum pot…
Amiloride + Trandolapril Tablets— Potassium-sparing diuretic that increases risk of hyperkalemia when used with ACE inhibitors. Use with caution and monit…

Amiloride + Potassium Chloride⛔Contraindicated

Concomitant use can produce severe hyperkalemia. Contraindicated.

Amiloride + Potassium Citrate⛔Contraindicated

Concomitant administration can produce severe hyperkalemia and should be avoided.

Amiloride + Amlodipine And Benazepril Hydrochloride⚠️Major

Potassium-sparing diuretic can increase the risk of hyperkalemia. Frequent monitoring of serum potassium is recommended if concomitant use is indicated.

Amiloride + Captopril And Hydrochlorothiazide⚠️Major

May cause significant increase in serum potassium. Should only be given for documented hypokalemia and with caution due to risk of hyperkalemia.

Amiloride + Enalapril⚠️Major

Potassium-sparing diuretic may lead to significant increases in serum potassium. Avoid in heart failure patients.

Amiloride + Enalapril Maleate⚠️Major

Potassium-sparing diuretic may lead to significant increases in serum potassium when used with enalapril.

Amiloride + Fosinopril⚠️Major

Potassium-sparing diuretic that can increase risk of hyperkalemia when used with fosinopril. Requires caution and frequent monitoring of serum potassium levels.

Amiloride + Lisinopril⚠️Major

Potassium-sparing diuretic can increase risk of hyperkalemia when used with lisinopril; requires frequent monitoring of serum potassium.

Amiloride + Lisinopril And Hydrochlorothiazide Tablets⚠️Major

Potassium-sparing diuretic may lead to significant hyperkalemia when used with lisinopril which attenuates potassium loss.

Amiloride + Losartan Potassium⚠️Major

Concomitant use may lead to increases in serum potassium, which can be serious.

Amiloride + Olmesartan Medoxomil⚠️Major

Potassium-sparing diuretic may lead to increases in serum potassium. Monitoring of serum potassium is advisable.

Amiloride + Perindopril Erbumine⚠️Major

Risk of hyperkalemia. Perindopril may increase serum potassium by decreasing aldosterone production.

Amiloride + Ramipril⚠️Major

Potassium-sparing diuretic increases risk of hyperkalemia. Frequent monitoring of serum potassium recommended if concomitant use indicated.

Amiloride + Sacubitril And Valsartan⚠️Major

May lead to increased serum potassium levels. Monitor potassium levels during concomitant use.

Amiloride + Sodium Chloride, Sodium Lactate, Potassium Chloride, Calcium Chloride And Dextrose Monohydrate⚠️Major

Increased risk of severe and potentially fatal hyperkalemia when potassium chloride solution is administered.

Amiloride + Trandolapril⚠️Major

Potassium-sparing diuretic increases risk of hyperkalemia when used with trandolapril; requires caution and appropriate serum potassium monitoring.

Amiloride + Valsartan⚠️Major

Potassium-sparing diuretic may lead to increases in serum potassium and in heart failure patients, increases in serum creatinine. Monitoring of serum potassium is advisable.

Amiloride + Valsartan And Hydrochlorothiazide⚠️Major

Potassium-sparing diuretic may lead to increases in serum potassium and in heart failure patients to increases in serum creatinine when used with valsartan.

Amiloride + Amlodipine And Valsartan🟡Moderate

Potassium-sparing diuretic that may increase serum potassium when combined with valsartan. Monitor serum potassium levels.

Amiloride + Benazepril Hydrochloride🟡Moderate

Increased risk of hyperkalemia. Monitor serum potassium frequently during concomitant use.

Amiloride + Enalapril Maleate And Hydrochlorothiazide🟡Moderate

Potassium-sparing diuretic may lead to significant increases in serum potassium when used concomitantly with enalapril; requires frequent monitoring.

Amiloride + Enalapril Maleate Oral Solution🟡Moderate

Potassium-sparing diuretic may lead to significant increases in serum potassium when combined with enalapril. Avoid in heart failure patients.

Amiloride + Enalaprilat🟡Moderate

Potassium-sparing diuretic may lead to significant increases in serum potassium when used concomitantly with enalaprilat. Use with caution and monitor serum potassium frequently.

Amiloride + Fosinopril Sodium🟡Moderate

Potassium-sparing diuretic that can increase risk of hyperkalemia when combined with fosinopril. Serum potassium should be monitored frequently.

Amiloride + Fosinopril Sodium And Hydrochlorothiazide🟡Moderate

Potassium-sparing diuretic may increase risk of hyperkalemia when used with fosinopril sodium and hydrochlorothiazide; requires monitoring of serum potassium.

Amiloride + Leucine, Phenylalanine, Lysine, Methionine, Isoleucine, Valine, Histidine, Threonine, Tryptophan, Alanine, Glycine, Arginine, Proline, Serine, Tyrosine, Dibasic Potassium Phosphate, Magnesium Chloride, Sodium Chloride, Calcium Chloride, Dextrose🟡Moderate

Potassium-sparing diuretic may increase risk of hyperkalemia when used with CLINIMIX E due to its potassium content; administer with caution.

Amiloride + Metformin Hydrochloride🟡Moderate

Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for common renal tubular transport systems.

Amiloride + Moexipril Hydrochloride🟡Moderate

Potassium-sparing diuretic may increase risk of hyperkalemia when used concomitantly with moexipril. Requires caution and monitoring of serum potassium levels.

Amiloride + Quinapril🟡Moderate

Potassium-sparing diuretic may increase serum potassium when used with quinapril. Use with caution and monitor serum potassium appropriately.

Amiloride + Trandolapril Tablets🟡Moderate

Potassium-sparing diuretic that increases risk of hyperkalemia when used with ACE inhibitors. Use with caution and monitor serum potassium.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.