Does Fosinopril Sodium And Hydrochlorothiazide Interact with Amiloride?
Fosinopril Sodium And Hydrochlorothiazide and Amiloride have a moderate drug interaction according to U.S. FDA drug labeling data. Potassium-sparing diuretic may increase risk of hyperkalemia when used with fosinopril sodium and hydrochlorothiazide; requires monitoring of serum potassium. The mechanism involves ace inhibitor and thiazide combination may elevate serum potassium; potassium-sparing diuretic further increases this risk. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Fosinopril Sodium And Hydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Fosinopril Sodium And Hydrochlorothiazide and Amiloride occurs because ace inhibitor and thiazide combination may elevate serum potassium; potassium-sparing diuretic further increases this risk. Clinically, this means potassium-sparing diuretic may increase risk of hyperkalemia when used with fosinopril sodium and hydrochlorothiazide; requires monitoring of serum potassium. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Fosinopril Sodium And Hydrochlorothiazide and your doctor is considering prescribing Amiloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider