Home›Captopril And Hydrochlorothiazide›Captopril And Hydrochlorothiazide + Amiloride

Does Captopril And Hydrochlorothiazide Interact with Amiloride?

Captopril And Hydrochlorothiazide and Amiloride have a major drug interaction according to U.S. FDA drug labeling data. May cause significant increase in serum potassium. Should only be given for documented hypokalemia and with caution due to risk of hyperkalemia. The mechanism involves captopril decreases aldosterone production; amiloride is potassium-sparing. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Captopril And Hydrochlorothiazide Class
Thiazide Diuretic
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Captopril And Hydrochlorothiazide and Amiloride occurs because captopril decreases aldosterone production; amiloride is potassium-sparing. Clinically, this means may cause significant increase in serum potassium. should only be given for documented hypokalemia and with caution due to risk of hyperkalemia. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Captopril And Hydrochlorothiazide and your doctor is considering prescribing Amiloride (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Captopril And Hydrochlorothiazide(Captopril And Hydrochlorothiazide)+💊 Amiloride

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Thiazide Diuretic
Drug B class
—
Source
NLP:captopril and hydrochlorothiazide

What this means in plain English

May cause significant increase in serum potassium. Should only be given for documented hypokalemia and with caution due to risk of hyperkalemia.

What the FDA label says

"Captopril decreases aldosterone production; amiloride is potassium-sparing"

📖 Source: NLP:captopril and hydrochlorothiazide

Share this result:XFacebookWhatsAppReddit
Add more drugs
Check Captopril And Hydrochlorothiazide and Amiloride against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.