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Vancomycin Hydrochloride

Also known as: Vancomycin Hydrochloride

Glycopeptide Antibacterial

Route: Oral

Check Vancomycin Hydrochloride Interactions →

10 interactions on record

Vancomycin Hydrochloride has 10 known drug interactions based on U.S. FDA drug labeling data. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amphotericin B, Bacitracin, Cisplatin. Patients taking Vancomycin Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 10
Major: 7
Moderate: 3

Major (7)

Vancomycin Hydrochloride + Amphotericin B— Potentially nephrotoxic and neurotoxic drug requiring renal function monitoring when used concurrently with vancomycin.
Vancomycin Hydrochloride + Bacitracin— Potentially nephrotoxic and neurotoxic drug requiring renal function monitoring when used concurrently with vancomycin.
Vancomycin Hydrochloride + Cisplatin— Potentially nephrotoxic and neurotoxic drug requiring renal function monitoring when used concurrently with vancomycin.
Vancomycin Hydrochloride + Colistin— Potentially nephrotoxic and neurotoxic drug requiring renal function monitoring when used concurrently with vancomycin.
Vancomycin Hydrochloride + Piperacillin And Tazobactam— Increased incidence of acute kidney injury compared to vancomycin alone. Monitor kidney function in patients receiving c…
Vancomycin Hydrochloride + Polymyxins— Potentially nephrotoxic and neurotoxic drug requiring renal function monitoring when used concurrently with vancomycin.
Vancomycin Hydrochloride + Topical Local Anesthetics— Concomitant administration associated with erythema, histamine-like flushing, and anaphylactoid reactions.

Moderate (3)

Vancomycin Hydrochloride + Ototoxic And/Or Nephrotoxic Drugs— Concurrent or sequential use requires more frequent monitoring of renal function due to potential additive nephrotoxicit…
Vancomycin Hydrochloride + Piperacillin— ( 2.1 , 7.1 ) • Piperacillin/Tazobactam : Increased incidence of acute kidney injury in patients receiving concomitant p…
Vancomycin Hydrochloride + Vancomycin— Drug Interactions Concomitant administration of vancomycin and anesthetic agents has been associated with erythema and h…

Vancomycin Hydrochloride + Amphotericin B⚠️Major

Potentially nephrotoxic and neurotoxic drug requiring renal function monitoring when used concurrently with vancomycin.

Vancomycin Hydrochloride + Bacitracin⚠️Major

Potentially nephrotoxic and neurotoxic drug requiring renal function monitoring when used concurrently with vancomycin.

Vancomycin Hydrochloride + Cisplatin⚠️Major

Potentially nephrotoxic and neurotoxic drug requiring renal function monitoring when used concurrently with vancomycin.

Vancomycin Hydrochloride + Colistin⚠️Major

Potentially nephrotoxic and neurotoxic drug requiring renal function monitoring when used concurrently with vancomycin.

Vancomycin Hydrochloride + Piperacillin And Tazobactam⚠️Major

Increased incidence of acute kidney injury compared to vancomycin alone. Monitor kidney function in patients receiving concomitant therapy.

Vancomycin Hydrochloride + Polymyxins⚠️Major

Potentially nephrotoxic and neurotoxic drug requiring renal function monitoring when used concurrently with vancomycin.

Vancomycin Hydrochloride + Topical Local Anesthetics⚠️Major

Concomitant administration associated with erythema, histamine-like flushing, and anaphylactoid reactions.

Vancomycin Hydrochloride + Ototoxic And/Or Nephrotoxic Drugs🟡Moderate

Concurrent or sequential use requires more frequent monitoring of renal function due to potential additive nephrotoxicity and neurotoxicity.

Vancomycin Hydrochloride + Piperacillin🟡Moderate

( 2.1 , 7.1 ) • Piperacillin/Tazobactam : Increased incidence of acute kidney injury in patients receiving concomitant piperacillin/tazobactam and vancomycin as compared to vancomycin alone. 7.2 Piperacillin-Tazobactam Studies have detected an increased incidence of acute kidney injury in patients administered concomitant piperacillin/tazobactam and vancomycin as compared to vancomycin alone. Monitor kidney function in patients receiving concomitant piperacillin/tazobactam and vancomycin.

Vancomycin Hydrochloride + Vancomycin🟡Moderate

Drug Interactions Concomitant administration of vancomycin and anesthetic agents has been associated with erythema and histamine-like flushing (see P ediatric Use - PRECAUTIONS ) and anaphylactoid reactions (see ADVERSE REACTIONS ). Monitor renal function in patients receiving vancomycin and concurrent and/or sequential systemic or topical use of other potentially, neurotoxic and/or nephrotoxic drugs, such as amphotericin B, aminoglycosides, bacitracin, polymyxin B, colistin, viomycin, or cisplatin.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.