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Does Vancomycin Hydrochloride Interact with Amphotericin B?

Vancomycin Hydrochloride and Amphotericin B have a major drug interaction according to U.S. FDA drug labeling data. Potentially nephrotoxic and neurotoxic drug requiring renal function monitoring when used concurrently with vancomycin. The mechanism involves additive nephrotoxic and neurotoxic effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Vancomycin Hydrochloride Class
Glycopeptide Antibacterial
Amphotericin B Class
Lipid-based Polyene Antifungal
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Vancomycin Hydrochloride and Amphotericin B occurs because additive nephrotoxic and neurotoxic effects. Clinically, this means potentially nephrotoxic and neurotoxic drug requiring renal function monitoring when used concurrently with vancomycin. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Vancomycin Hydrochloride and your doctor is considering prescribing Amphotericin B (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Vancomycin Hydrochloride(Vancomycin Hydrochloride)+💊 Amphotericin B(Amphotericin B)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Glycopeptide Antibacterial
Drug B class
Lipid-based Polyene Antifungal
Source
NLP:vancomycin hydrochloride

What this means in plain English

Potentially nephrotoxic and neurotoxic drug requiring renal function monitoring when used concurrently with vancomycin.

What the FDA label says

"Additive nephrotoxic and neurotoxic effects"

📖 Source: NLP:vancomycin hydrochloride

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.