Does Ototoxic Andor Nephrotoxic Drugs Interact with Vancomycin Hydrochloride?
Ototoxic Andor Nephrotoxic Drugs and Vancomycin Hydrochloride have a moderate drug interaction according to U.S. FDA drug labeling data. Concurrent or sequential use requires more frequent monitoring of renal function due to potential additive nephrotoxicity and neurotoxicity. The mechanism involves additive nephrotoxic and neurotoxic effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Vancomycin Hydrochloride Class
- Glycopeptide Antibacterial
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Ototoxic Andor Nephrotoxic Drugs and Vancomycin Hydrochloride occurs because additive nephrotoxic and neurotoxic effects. Clinically, this means concurrent or sequential use requires more frequent monitoring of renal function due to potential additive nephrotoxicity and neurotoxicity. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Ototoxic Andor Nephrotoxic Drugs and your doctor is considering prescribing Vancomycin Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider