Desvenlafaxine Succinate has 25 known drug interactions based on U.S. FDA drug labeling data. Of these, 6 are contraindicated combinations that should be avoided entirely. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Isocarboxazid, Linezolid, Methylene Blue. Patients taking Desvenlafaxine Succinate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 25
- Contraindicated
- 6
- Major
- 8
- Moderate
- 9
Contraindicated (6)
- Desvenlafaxine Succinate + Isocarboxazid— Concomitant use increases risk of serotonin syndrome. Contraindicated with MAOI intended to treat psychiatric disorders …
- Desvenlafaxine Succinate + Linezolid— Concomitant use is contraindicated due to increased risk of serotonin syndrome.
- Desvenlafaxine Succinate + Methylene Blue— Concomitant intravenous methylene blue is contraindicated due to increased risk of serotonin syndrome.
- Desvenlafaxine Succinate + Phenelzine— Concomitant use increases risk of serotonin syndrome. Contraindicated with MAOI intended to treat psychiatric disorders …
- Desvenlafaxine Succinate + Selegiline— Concomitant use increases risk of serotonin syndrome. Contraindicated with MAOI intended to treat psychiatric disorders …
- Desvenlafaxine Succinate + Tranylcypromine— Concomitant use increases risk of serotonin syndrome. Contraindicated with MAOI intended to treat psychiatric disorders …
Major (8)
- Desvenlafaxine Succinate + Amphetamine— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
- Desvenlafaxine Succinate + Buspirone— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
- Desvenlafaxine Succinate + Fentanyl— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
- Desvenlafaxine Succinate + Lithium— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
- Desvenlafaxine Succinate + St. John'S Wort— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
- Desvenlafaxine Succinate + Tramadol— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
- Desvenlafaxine Succinate + Triptans— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
- Desvenlafaxine Succinate + Tryptophan— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
Moderate (9)
- Desvenlafaxine Succinate + Acetylsalicylic Acid— Concomitant use may potentiate bleeding risk. Closely monitor for bleeding when desvenlafaxine is initiated or discontin…
- Desvenlafaxine Succinate + Atomoxetine— Concomitant use increases exposure (Cmax and AUC). Reduce dose by up to one-half if co-administered with 400 mg desvenla…
- Desvenlafaxine Succinate + Desipramine— Concomitant use increases exposure (Cmax and AUC). Reduce dose by up to one-half if co-administered with 400 mg desvenla…
- Desvenlafaxine Succinate + Dextromethorphan— Concomitant use increases exposure (Cmax and AUC). Reduce dose by up to one-half if co-administered with 400 mg desvenla…
- Desvenlafaxine Succinate + Metoprolol— Concomitant use increases exposure (Cmax and AUC). Reduce dose by up to one-half if co-administered with 400 mg desvenla…
- Desvenlafaxine Succinate + Nebivolol— Concomitant use increases exposure (Cmax and AUC). Reduce dose by up to one-half if co-administered with 400 mg desvenla…
- Desvenlafaxine Succinate + Perphenazine— Concomitant use increases exposure (Cmax and AUC). Reduce dose by up to one-half if co-administered with 400 mg desvenla…
- Desvenlafaxine Succinate + Tolterodine— Concomitant use increases exposure (Cmax and AUC). Reduce dose by up to one-half if co-administered with 400 mg desvenla…
- Desvenlafaxine Succinate + Warfarin— Concomitant use may potentiate bleeding risk. Closely monitor for bleeding when desvenlafaxine is initiated or discontin…