Does Desvenlafaxine Succinate Interact with Perphenazine?
Desvenlafaxine Succinate and Perphenazine have a moderate drug interaction according to U.S. FDA drug labeling data. Concomitant use increases exposure (Cmax and AUC). Reduce dose by up to one-half if co-administered with 400 mg desvenlafaxine. The mechanism involves desvenlafaxine inhibits cyp2d6 metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Perphenazine Class
- Phenothiazine
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Desvenlafaxine Succinate and Perphenazine occurs because desvenlafaxine inhibits cyp2d6 metabolism. Clinically, this means concomitant use increases exposure (cmax and auc). reduce dose by up to one-half if co-administered with 400 mg desvenlafaxine. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Desvenlafaxine Succinate and your doctor is considering prescribing Perphenazine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider