Does Amitriptyline Interact with Clonidine Transdermal System?
Amitriptyline and Clonidine Transdermal System have a unknown drug interaction according to U.S. FDA drug labeling data. Amitriptyline in combination with clonidine enhances manifestation of corneal lesions in rats. The mechanism involves enhancement of corneal lesions. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Clonidine Transdermal System Class
- Central alpha-2 Adrenergic Agonist
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Amitriptyline and Clonidine Transdermal System occurs because enhancement of corneal lesions. Clinically, this means amitriptyline in combination with clonidine enhances manifestation of corneal lesions in rats.
What To Tell Your Doctor or Pharmacist
If you are taking Amitriptyline and your doctor is considering prescribing Clonidine Transdermal System (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider