Nitroglycerin Lingual + AvanafilContraindicated
PDE5 inhibitor that potentiates hypotensive effects of nitroglycerin. Concomitant use is contraindicated.
Source: NLP:nitroglycerin lingual
Nitroglycerin Lingual Interactions
Brand names: Nitroglycerin Lingual
Nitrate Vasodilator
Route: Oral
Contraindications
4 CONTRAINDICATIONS 4.1 PDE-5-Inhibitors and sGC-Stimulators Do not use Nitroglycerin Lingual Spray in patients who are taking PDE-5 inhibitors, such as avanafil, sildenafil, tadalafil, or vardenafil. Concomitant use can cause severe hypotension, syncope, or myocardial ischemia [see Drug Interactions (7.1)]. Do not use Nitroglycerin Lingual Spray in patients who are taking the soluble guanylate cyclase (sGC) stimulator riociguat. Concomitant use can cause hypotension. 4.2 Severe Anemia Nitroglycerin Lingual Spray is contraindicated in patients with severe anemia (large doses of nitroglycerin may cause oxidation of hemoglobin to methemoglobin and could exacerbate anemia). 4.3 Increased Intracranial Pressure Nitroglycerin Lingual Spray may precipitate or aggravate increased intracranial pressure and thus should not be used in patients with possible increased intracranial pressure (e. g. cerebral hemorrhage or traumatic brain injury). 4.4 Hypersensitivity Nitroglycerin Lingual Spray is contraindicated in patients who are allergic to nitroglycerin, other nitrates or nitrites or any excipient. 4.5 Circulatory Failure and Shock Nitroglycerin Lingual Spray is contraindicated in patients with acute circulatory failure or shock.
10 interactions on record
Nitroglycerin Lingual + RiociguatContraindicated
sGC stimulator. Concomitant use with nitroglycerin can cause hypotension and is contraindicated.
Source: NLP:nitroglycerin lingual
Nitroglycerin Lingual + SildenafilContraindicated
PDE5 inhibitor that potentiates hypotensive effects of nitroglycerin. Concomitant use is contraindicated.
Source: NLP:nitroglycerin lingual
sGC stimulators are contraindicated with nitroglycerin. Concomitant use can cause severe hypotension.
Source: NLP:nitroglycerin lingual
Nitroglycerin Lingual + TadalafilContraindicated
PDE5 inhibitor that potentiates hypotensive effects of nitroglycerin. Concomitant use is contraindicated.
Source: NLP:nitroglycerin lingual
Nitroglycerin Lingual + VardenafilContraindicated
PDE5 inhibitor that potentiates hypotensive effects of nitroglycerin. Concomitant use is contraindicated.
Source: NLP:nitroglycerin lingual
Marked orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used concomitantly.
Source: NLP:nitroglycerin lingual
Oral nitroglycerin markedly decreases first-pass metabolism and increases oral bioavailability. Related to ergotamine; monitor for symptoms of ergotism.
Source: NLP:nitroglycerin lingual
Nitroglycerin decreases first-pass metabolism of ergotamine, increasing bioavailability. Ergotamine may precipitate angina pectoris; monitor or avoid concomitant use.
Source: NLP:nitroglycerin lingual
May cause additional hypotensive effects when used with nitroglycerin. Beta-blockers blunt reflex tachycardia without preventing hypotensive effects.
Source: NLP:nitroglycerin lingual