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Does Sildenafil Interact with Nitroglycerin Lingual?

Sildenafil and Nitroglycerin Lingual have a contraindicated drug interaction according to U.S. FDA drug labeling data. PDE5 inhibitor that potentiates hypotensive effects of nitroglycerin. Concomitant use is contraindicated. The mechanism involves potentiation of hypotensive effects via cgmp-specific phosphodiesterase type 5 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Sildenafil Class
Phosphodiesterase 5 Inhibitor
Nitroglycerin Lingual Class
Nitrate Vasodilator
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Sildenafil and Nitroglycerin Lingual occurs because potentiation of hypotensive effects via cgmp-specific phosphodiesterase type 5 inhibition. Clinically, this means pde5 inhibitor that potentiates hypotensive effects of nitroglycerin. concomitant use is contraindicated. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Sildenafil and your doctor is considering prescribing Nitroglycerin Lingual (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Sildenafil(Sildenafil Citrate)+💊 Nitroglycerin Lingual(Nitroglycerin Lingual)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Phosphodiesterase 5 Inhibitor
Drug B class
Nitrate Vasodilator
Source
NLP:nitroglycerin lingual

What this means in plain English

PDE5 inhibitor that potentiates hypotensive effects of nitroglycerin. Concomitant use is contraindicated.

What the FDA label says

"Potentiation of hypotensive effects via cGMP-specific phosphodiesterase type 5 inhibition"

📖 Source: NLP:nitroglycerin lingual

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.