Does Ergotamine Interact with Nitroglycerin Lingual?
Ergotamine and Nitroglycerin Lingual have a moderate drug interaction according to U.S. FDA drug labeling data. Nitroglycerin decreases first-pass metabolism of ergotamine, increasing bioavailability. Ergotamine may precipitate angina pectoris; monitor or avoid concomitant use. The mechanism involves decreased first-pass metabolism of ergotamine. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Nitroglycerin Lingual Class
- Nitrate Vasodilator
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Ergotamine and Nitroglycerin Lingual occurs because decreased first-pass metabolism of ergotamine. Clinically, this means nitroglycerin decreases first-pass metabolism of ergotamine, increasing bioavailability. ergotamine may precipitate angina pectoris; monitor or avoid concomitant use. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Ergotamine and your doctor is considering prescribing Nitroglycerin Lingual (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider