Piperacillin And Tazobactam has 11 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Probenecid, Tobramycin, Vancomycin. Patients taking Piperacillin And Tazobactam should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 11
- Contraindicated
- 1
- Major
- 4
- Moderate
- 6
Contraindicated (1)
- Piperacillin And Tazobactam + Probenecid— Probenecid prolongs half-lives of piperacillin by 21% and tazobactam by 71%. Should not be co-administered unless benefi…
Major (4)
- Piperacillin And Tazobactam + Tobramycin— Piperacillin may inactivate tobramycin by converting it to microbiologically inert amides. In hemodialysis patients, tob…
- Piperacillin And Tazobactam + Vancomycin— Co-administration increases incidence of acute kidney injury compared to vancomycin alone. Monitor kidney function in pa…
- Piperacillin And Tazobactam + Vancomycin Hydrochloride— Increased incidence of acute kidney injury compared to vancomycin alone. Monitor kidney function in patients receiving c…
- Piperacillin And Tazobactam + Vecuronium— Piperacillin may prolong the neuromuscular blockade of vecuronium. Monitor for adverse reactions related to neuromuscula…
Moderate (6)
- Piperacillin And Tazobactam + Amikacin— Piperacillin and tazobactam may inactivate amikacin in vitro. Separate administration is recommended, though compatibili…
- Piperacillin And Tazobactam + Bromide— Monitor for adverse reactions related to neuromuscular blockade (see package insert for vecuronium bromide).
- Piperacillin And Tazobactam + Gentamicin— Piperacillin and tazobactam may inactivate gentamicin in vitro. Separate administration is recommended, though compatibi…
- Piperacillin And Tazobactam + Heparin— Monitor coagulation parameters in patients receiving piperacillin and tazobactam with heparin.
- Piperacillin And Tazobactam + Oral Anticoagulants— Monitor coagulation parameters in patients receiving piperacillin and tazobactam with oral anticoagulants.
- Piperacillin And Tazobactam + Piperacillin— 7 DRUG INTERACTIONS Piperacillin and Tazobactam for Injection administration can significantly reduce tobramycin concent…