Does Tobramycin Interact with Piperacillin And Tazobactam?
CDI records a major classification for Tobramycin and Piperacillin And Tazobactam. The stored summary is: Piperacillin may inactivate tobramycin by converting it to microbiologically inert amides. In hemodialysis patients, tobramycin concentrations may be significantly reduced and require monitoring. The mechanism involves in vivo inactivation of aminoglycosides by piperacillin converting them to microbiologically inert amides. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Tobramycin Class
- Aminoglycoside Antibacterial
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
In vivo inactivation of aminoglycosides by piperacillin converting them to microbiologically inert amides
What To Tell Your Doctor or Pharmacist
If you are taking Tobramycin and your doctor is considering prescribing Piperacillin And Tazobactam (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider