Does Amikacin Interact with Piperacillin And Tazobactam?
CDI records a moderate classification for Amikacin and Piperacillin And Tazobactam. The stored summary is: Piperacillin and tazobactam may inactivate amikacin in vitro. Separate administration is recommended, though compatibility exists for simultaneous Y-site infusion in certain diluents and concentrations. The mechanism involves in vitro inactivation of aminoglycosides by piperacillin. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Amikacin Class
- Aminoglycoside Antibacterial
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
In vitro inactivation of aminoglycosides by piperacillin
What To Tell Your Doctor or Pharmacist
If you are taking Amikacin and your doctor is considering prescribing Piperacillin And Tazobactam (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider