Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate has 46 known drug interactions based on U.S. FDA drug labeling data. Of these, 10 are contraindicated combinations that should be avoided entirely. 20 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Isocarboxazid, Linezolid, Mao Inhibitors. Patients taking Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 46
- Contraindicated
- 10
- Major
- 20
- Moderate
- 15
Contraindicated (10)
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Isocarboxazid— MAOI that potentiates amphetamine effects; concomitant use can cause hypertensive crisis with potentially fatal outcomes…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Linezolid— MAOI that potentiates amphetamine effects; concomitant use can cause hypertensive crisis with potentially fatal outcomes…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Mao Inhibitors— Concomitant use can cause hypertensive crisis with potential outcomes including death, stroke, myocardial infarction, ao…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Maois— Concomitant use can cause hypertensive crisis with potentially fatal outcomes including death, stroke, myocardial infarc…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Methylene Blue— MAOI that potentiates amphetamine effects; concomitant use can cause hypertensive crisis with potentially fatal outcomes…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Monoamine Oxidase Inhibitors (Maois)— Concomitant use can cause hypertensive crisis with potentially fatal outcomes including death, stroke, myocardial infarc…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Phenelzine— MAOI that potentiates amphetamine effects; concomitant use can cause hypertensive crisis with potentially fatal outcomes…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Selegiline— MAOI that potentiates amphetamine effects; concomitant use can cause hypertensive crisis with potentially fatal outcomes…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Sodium Bicarbonate— Gastrointestinal alkalinizing agent that increases amphetamine blood levels and potentiates action. Co-administration sh…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Tranylcypromine— MAOI that potentiates amphetamine effects; concomitant use can cause hypertensive crisis with potentially fatal outcomes…
Major (20)
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Acetazolamide— Urinary alkalinizing agent that increases blood levels and potentiates amphetamine action. Co-administration should be a…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Alkalinizing Agents— Increase blood levels and potentiate the action of amphetamine. Co-administration should be avoided.
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Buspirone— Serotonergic drug that increases risk of serotonin syndrome when combined with amphetamines. Initiate with lower doses a…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Desipramine— Tricyclic antidepressant may enhance activity causing striking sustained increases in d-amphetamine concentration and po…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Fentanyl— Serotonergic drug that increases risk of serotonin syndrome when combined with amphetamines. Initiate with lower doses a…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Fluoxetine— CYP2D6 inhibitor and serotonergic drug that increases amphetamine exposure and risk of serotonin syndrome. Initiate with…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Lithium— Serotonergic drug that increases risk of serotonin syndrome when combined with amphetamines. Initiate with lower doses a…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Lovastatin— There has been one report of severe congenital bony deformity, tracheo-esophageal fistula, and anal atresia (vater assoc…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Meperidine— Opioid whose effects may be potentiated by amphetamines, with serotonergic properties increasing serotonin syndrome risk…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Norepinephrine— Effects may be potentiated by amphetamines.
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Paroxetine— CYP2D6 inhibitor and serotonergic drug that increases amphetamine exposure and risk of serotonin syndrome. Initiate with…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Protriptyline— Tricyclic antidepressant may enhance activity causing striking sustained increases in d-amphetamine concentration and po…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Quinidine— CYP2D6 inhibitor that increases amphetamine exposure and risk of serotonin syndrome. Initiate with lower doses and monit…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Ritonavir— CYP2D6 inhibitor that increases amphetamine exposure and risk of serotonin syndrome. Initiate with lower doses and monit…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Selective Serotonin Reuptake Inhibitors (Ssri)— Concomitant use increases the risk of serotonin syndrome. Monitor for signs and symptoms, particularly during initiation…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + St. John'S Wort— Serotonergic drug that increases risk of serotonin syndrome when combined with amphetamines. Initiate with lower doses a…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Thiazides— Some thiazides are urinary alkalinizing agents that increase amphetamine blood levels and potentiate action. Co-administ…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Tramadol— Serotonergic drug that increases risk of serotonin syndrome when combined with amphetamines. Initiate with lower doses a…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Triptans— Concomitant use increases the risk of serotonin syndrome. Monitor for signs and symptoms, particularly during initiation…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Tryptophan— Serotonergic drug that increases risk of serotonin syndrome when combined with amphetamines. Initiate with lower doses a…
Moderate (15)
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Acidifying Agents— Lower blood levels and efficacy of amphetamines. Dose adjustment based on clinical response may be needed.
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Adrenergic Blockers— Adrenergic blockers are inhibited by amphetamines, potentially reducing their therapeutic effect.
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Ammonium Chloride— Urinary acidifying agent that lowers blood levels and efficacy of amphetamines. Dose adjustment may be needed based on c…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Ascorbic Acid— Acidifying agent that lowers blood levels and efficacy of amphetamines. Dose adjustment may be needed based on clinical …
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Ethosuximide— Amphetamines may reduce the effects of this drug. Monitor for reduced efficacy.
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Gastric Ph Modulators (H2-Blockers, Proton Pump Inhibitors)— Potential change in pharmacokinetic profile and exposure may occur. Monitor for changes in clinical effect.
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Glutamic Acid Hcl— Acidifying agent that lowers blood levels and efficacy of amphetamines. Dose adjustment may be needed based on clinical …
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Guanethidine— Acidifying agent that lowers blood levels and efficacy of amphetamines. Dose adjustment may be needed based on clinical …
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Methenamine Salts— Urinary acidifying agent that lowers blood levels and efficacy of amphetamines. Dose adjustment may be needed based on c…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Phenobarbital— Amphetamines may reduce the effects of this drug. Monitor for reduced efficacy.
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Phenytoin— Amphetamines may reduce the effects of this drug. Monitor for reduced efficacy.
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Reserpine— Acidifying agent that lowers blood levels and efficacy of amphetamines. Dose adjustment may be needed based on clinical …
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Sodium Acid Phosphate— Urinary acidifying agent that lowers blood levels and efficacy of amphetamines. Dose adjustment may be needed based on c…
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Urinary Alkalinizing Agents— Increase blood levels and potentiate the action of amphetamine.
- Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate + Veratrum Alkaloids— Effects of veratrum alkaloids may be reduced by amphetamines.