Home›Monoamine Oxidase Inhibitors Maois›Monoamine Oxidase Inhibitors Maois + Dextroamphetamine Saccharate Amphetamine Aspartate Monohydra

Does Monoamine Oxidase Inhibitors Maois Interact with Dextroamphetamine Saccharate Amphetamine Aspartate Monohydra?

Monoamine Oxidase Inhibitors Maois and Dextroamphetamine Saccharate Amphetamine Aspartate Monohydra have a contraindicated drug interaction according to U.S. FDA drug labeling data. Concomitant use can cause hypertensive crisis with potentially fatal outcomes including death, stroke, myocardial infarction, and aortic dissection. Do not use concomitantly or within 14 days of MAOI discontinuation. The mechanism involves increased sympathomimetic activity. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Monoamine Oxidase Inhibitors Maois and Dextroamphetamine Saccharate Amphetamine Aspartate Monohydra occurs because increased sympathomimetic activity. Clinically, this means concomitant use can cause hypertensive crisis with potentially fatal outcomes including death, stroke, myocardial infarction, and aortic dissection. do not use concomitantly or within 14 days of maoi discontinuation. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Monoamine Oxidase Inhibitors Maois and your doctor is considering prescribing Dextroamphetamine Saccharate Amphetamine Aspartate Monohydra (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Monoamine Oxidase Inhibitors Maois+💊 Dextroamphetamine Saccharate Amphetamine Aspartate Monohydra(Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:dextroamphetamine sulfate, dextroamphetamine saccharate, amphetamine sulfate and amphetamine aspartate

What this means in plain English

Concomitant use can cause hypertensive crisis with potentially fatal outcomes including death, stroke, myocardial infarction, and aortic dissection. Do not use concomitantly or within 14 days of MAOI discontinuation.

What the FDA label says

"Increased sympathomimetic activity"

📖 Source: NLP:dextroamphetamine sulfate, dextroamphetamine saccharate, amphetamine sulfate and amphetamine aspartate

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.