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Does Abrocitinib Interact with Fluconazole?

Abrocitinib and Fluconazole have a contraindicated drug interaction according to U.S. FDA drug labeling data. Concomitant use increases systemic exposure of abrocitinib and active metabolites due to fluconazole's inhibition of CYP2C19, CYP2C9, and CYP3A4. Avoid concomitant use. The mechanism involves inhibition of cyp2c19 (strong), cyp2c9 (moderate), and cyp3a4 (moderate). Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Abrocitinib Class
Janus Kinase Inhibitor
Fluconazole Class
Azole Antifungal
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Abrocitinib and Fluconazole occurs because inhibition of cyp2c19 (strong), cyp2c9 (moderate), and cyp3a4 (moderate). Clinically, this means concomitant use increases systemic exposure of abrocitinib and active metabolites due to fluconazole's inhibition of cyp2c19, cyp2c9, and cyp3a4. avoid concomitant use. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Abrocitinib and your doctor is considering prescribing Fluconazole (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Abrocitinib(Cibinqo)+💊 Fluconazole(Diflucan)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Janus Kinase Inhibitor
Drug B class
Azole Antifungal
Source
NLP:fluconazole

What this means in plain English

Concomitant use increases systemic exposure of abrocitinib and active metabolites due to fluconazole's inhibition of CYP2C19, CYP2C9, and CYP3A4. Avoid concomitant use.

About Abrocitinib and Fluconazole

Abrocitinib is a Janus Kinase Inhibitor, while Fluconazole is an Azole Antifungal. You may recognize them by the brand names Cibinqo and Diflucan. Abrocitinib is taken by mouth, whereas Fluconazole is given by intravenous (IV) infusion. Abrocitinib additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"Inhibition of CYP2C19 (strong), CYP2C9 (moderate), and CYP3A4 (moderate)"

📖 Source: NLP:fluconazole

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.