Home›Clarithromycin›Clarithromycin + Fluconazole

Does Clarithromycin Interact with Fluconazole?

CDI records a contraindicated classification for Clarithromycin and Fluconazole. The stored summary is: Antifungals: Itraconazole Fluconazole Use With Caution No Dose Adjustment Itraconazole: Both clarithromycin and itraconazole are substrates and inhibitors of CYP3A, potentially leading to a bi-directional drug interaction when administered concomitantly (see also Itraconazole under “Drugs That Affect Clarithromycin” in the table below). Fluconazole: [see Pharmacokinetics (12.3) ] Anti-Gout Agents: Colchicine (in patients with renal or hepatic impairment) Colchicine (in patients with normal renal and hepatic function) Contraindicated Use With Caution Colchicine : Colchicine is a substrate for both CYP3A and the efflux transporter, P-glycoprotein (Pgp). Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.

Severity: Contraindicated
Clarithromycin Class: Macrolide Antimicrobial
Fluconazole Class: Azole Antifungal
Management: Do not take together
Data Source: U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Clarithromycin and your doctor is considering prescribing Fluconazole (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Ask about alternative medications that do not interact with your current regimen
Ask how frequently you should be monitored while these are co-prescribed
Never stop or change either medication without first consulting your healthcare provider

💊 Clarithromycin(Biaxin)+💊 Fluconazole(Diflucan)

Severity & Interaction Details

⛔

contraindicated

Avoid this combination

CDI classifies this record as contraindicated. Confirm the applicable product labeling with your prescriber or pharmacist.

Severity scale

MinorContra

On record

Yes

Drug A class

Macrolide Antimicrobial

Drug B class

Azole Antifungal

Source

FDA drug label - clarithromycin

What this means in plain English

Antifungals: Itraconazole Fluconazole Use With Caution No Dose Adjustment Itraconazole: Both clarithromycin and itraconazole are substrates and inhibitors of CYP3A, potentially leading to a bi-directional drug interaction when administered concomitantly (see also Itraconazole under “Drugs That Affect Clarithromycin” in the table below). Fluconazole: [see Pharmacokinetics (12.3) ] Anti-Gout Agents: Colchicine (in patients with renal or hepatic impairment) Colchicine (in patients with normal renal and hepatic function) Contraindicated Use With Caution Colchicine : Colchicine is a substrate for both CYP3A and the efflux transporter, P-glycoprotein (Pgp).

About Clarithromycin and Fluconazole

Clarithromycin is a Macrolide Antimicrobial, while Fluconazole is an Azole Antifungal. You may recognize them by the brand names Biaxin and Diflucan.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: FDA drug label - clarithromycin

Share this result:

WhatsApp Text / SMS Email

Also share on:X Facebook

Add more drugs

Check Clarithromycin and Fluconazole against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.