Home›Acetaminophen›Acetaminophen + Treprostinil

Does Acetaminophen Interact with Treprostinil?

Acetaminophen and Treprostinil have a minor drug interaction according to U.S. FDA drug labeling data. Co-administration did not show clinically significant effect on treprostinil pharmacokinetics. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Minor
Treprostinil Class
Prostacycline Vasodilator
Management
Generally manageable
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Acetaminophen and your doctor is considering prescribing Treprostinil (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Acetaminophen(Little Fevers)+💊 Treprostinil(Orenitram)

Severity & Interaction Details

✅
minor
Generally safe — minor interaction
Low clinical significance. Routine awareness is usually sufficient.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Prostacycline Vasodilator
Source
NLP:treprostinil

What this means in plain English

Co-administration did not show clinically significant effect on treprostinil pharmacokinetics.

About Acetaminophen and Treprostinil

Treprostinil is a Prostacycline Vasodilator. You may recognize them by the brand names Little Fevers and Orenitram. Acetaminophen is given by intravenous (IV) infusion, whereas Treprostinil is taken by mouth. Acetaminophen additionally carries an FDA boxed warning, the FDA's strongest safety alert.

Share this result:

WhatsAppText / SMSEmail
Also share on:XFacebook
Add more drugs
Check Acetaminophen and Treprostinil against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →
Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.