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Does Fluoxetine Interact with Monoamine Oxidase Inhibitors Maois?

Fluoxetine and Monoamine Oxidase Inhibitors Maois have a contraindicated drug interaction according to U.S. FDA drug labeling data. Contraindicated combination with fluoxetine due to risk of serotonin syndrome. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity: Contraindicated
Management: Do not take together
Data Source: U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Fluoxetine and your doctor is considering prescribing Monoamine Oxidase Inhibitors Maois (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Ask about alternative medications that do not interact with your current regimen
Ask how frequently you should be monitored while these are co-prescribed
Never stop or change either medication without first consulting your healthcare provider

💊 Fluoxetine(Symbyax)+💊 Monoamine Oxidase Inhibitors Maois

Severity & Interaction Details

⛔

contraindicated

Avoid this combination

FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.

Severity scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

—

Source

NLP:fluoxetine

What this means in plain English

Contraindicated combination with fluoxetine due to risk of serotonin syndrome.

About Fluoxetine and Monoamine Oxidase Inhibitors Maois

Fluoxetine is also sold under the brand name Symbyax. Fluoxetine is taken by mouth. Fluoxetine additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.