Does Acetylsalicylic Acid Interact with Alendronate Sodium?
Acetylsalicylic Acid and Alendronate Sodium have a moderate drug interaction according to U.S. FDA drug labeling data. Concomitant therapy with daily doses of alendronate sodium greater than 10 mg and aspirin-containing products increases incidence of upper gastrointestinal adverse events. The mechanism involves gastrointestinal irritation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Acetylsalicylic Acid and Alendronate Sodium occurs because gastrointestinal irritation. Clinically, this means concomitant therapy with daily doses of alendronate sodium greater than 10 mg and aspirin-containing products increases incidence of upper gastrointestinal adverse events. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Acetylsalicylic Acid and your doctor is considering prescribing Alendronate Sodium (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider