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Does Acetylsalicylic Acid Interact with Ibuprofen?

Acetylsalicylic Acid and Ibuprofen have a contraindicated drug interaction according to U.S. FDA drug labeling data. Cross reactivity between aspirin and NSAIDs including bronchospasm reported in aspirin-sensitive patients. Ibuprofen should not be administered to patients with aspirin sensitivity. The mechanism involves cross reactivity between aspirin and nsaids causing bronchospasm in aspirin-sensitive asthma patients. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Ibuprofen Class
Nonsteroidal Anti-inflammatory Drug
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Acetylsalicylic Acid and Ibuprofen occurs because cross reactivity between aspirin and nsaids causing bronchospasm in aspirin-sensitive asthma patients. Clinically, this means cross reactivity between aspirin and nsaids including bronchospasm reported in aspirin-sensitive patients. ibuprofen should not be administered to patients with aspirin sensitivity. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Acetylsalicylic Acid and your doctor is considering prescribing Ibuprofen (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Acetylsalicylic Acid+💊 Ibuprofen(Ibu)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Nonsteroidal Anti-inflammatory Drug
Source
NLP:ibuprofen

What this means in plain English

Cross reactivity between aspirin and NSAIDs including bronchospasm reported in aspirin-sensitive patients. Ibuprofen should not be administered to patients with aspirin sensitivity.

What the FDA label says

"Cross reactivity between aspirin and NSAIDs causing bronchospasm in aspirin-sensitive asthma patients"

📖 Source: NLP:ibuprofen

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.