Acetylsalicylic Acid Interactions

High-dose aspirin with dichlorphenamide is contraindicated due to risk of anorexia, tachypnea, lethargy, and coma. Low-dose aspirin requires careful monitoring.

Source: NLP:dichlorphenamide

Aspirin and other salicylate drugs are additive to salsalate and may increase plasma concentrations of salicylic acid to toxic levels. Concomitant administration is not generally recommended.

Source: NLP:salsalate

Concomitant use of ibuprofen and aspirin increases risk of GI adverse reactions and bleeding; no greater therapeutic benefit than NSAID alone.

Source: NLP:acetaminophen and ibuprofen

Concomitant use of NSAID and aspirin is associated with significantly increased incidence of GI adverse reactions and increased risk of bleeding.

Source: NLP:acetaminophen and ibuprofen injection

See WARNINGS section for detailed interaction information.

Source: NLP:acetazolamide

Increased risk of major hemorrhagic events; monitor for bleeding and assess hemorrhage risk before initiation.

Source: NLP:anagrelide

Increased risk of bleeding and major hemorrhagic events; greater anti-platelet aggregation when combined.

Source: NLP:anagrelide hydrochloride

Antiplatelet agent that increases bleeding risk when coadministered with apixaban. Concomitant use increased major bleeding risk from 1.8% to 3.4% per year.

Source: NLP:apixaban

Concomitant use of celecoxib and aspirin is associated with significantly increased incidence of GI adverse reactions and increased risk of bleeding.

Source: NLP:celecoxib

Concurrent use of aspirin with citalopram may potentiate the risk of upper gastrointestinal bleeding due to interference with serotonin reuptake and platelet hemostasis.

Source: NLP:citalopram

Concurrent use may potentiate risk of upper gastrointestinal bleeding due to interference with hemostasis and serotonin reuptake inhibition.

Source: NLP:citalopram hydrobromide

Concomitant use associated with significantly increased incidence of GI adverse reactions and increased risk of bleeding.

Source: NLP:diclofenac

Concomitant use associated with significantly increased incidence of GI adverse reactions and increased risk of bleeding.

Source: NLP:diclofenac epolamine

Concomitant use not generally recommended due to increased risk of bleeding and GI adverse reactions. No greater therapeutic benefit than NSAID alone.

Source: NLP:diclofenac potassium

Concomitant use associated with significantly increased incidence of GI adverse reactions and increased risk of bleeding.

Source: NLP:diclofenac sodium

Concomitant use of analgesic doses is not generally recommended due to increased risk of bleeding.

Source: NLP:diclofenac sodium, methyl salicylate

Concomitant use with analgesic doses of aspirin significantly increases incidence of GI adverse reactions and bleeding risk.

Source: NLP:diclofenac sodium and misoprostol

Concomitant use increases risk of bleeding and GI adverse reactions compared to NSAID alone. No greater therapeutic benefit than NSAID monotherapy.

Source: NLP:diclofenac sodium topical solution

Concomitant use associated with significantly increased incidence of GI adverse reactions and increased risk of bleeding.

Source: NLP:diclofenac sodium topical gel, 1%,

Concomitant use increases risk of bleeding and GI adverse reactions compared to NSAID alone. Not generally recommended at analgesic doses.

Source: NLP:diclofenac sodium, kinesiology tape

May enhance risk of hemorrhage. Discontinue prior to Lovenox initiation if possible, or conduct close clinical and laboratory monitoring if coadministration is essential.

Source: NLP:enoxaparin sodium

Coadministration increases the risk of bleeding.

Source: NLP:eptifibatide

Concurrent use may potentiate risk of upper gastrointestinal bleeding due to interference with hemostasis.

Source: NLP:escitalopram

Concomitant use of fenoprofen and analgesic doses of aspirin is associated with significantly increased incidence of GI adverse reactions and increased risk of bleeding.

Source: NLP:fenoprofen calcium

Possibility of increased bleeding due to pyridoxine interaction with anticoagulants.

Source: NLP:ferrous fumarate, folic acid

Concurrent use may potentiate risk of upper gastrointestinal bleeding due to interference with serotonin-mediated hemostasis.

Source: NLP:fluoxetine

Concurrent use may potentiate risk of upper gastrointestinal bleeding.

Source: NLP:fluoxetine hydrochloride

Increased incidence of GI adverse reactions and increased risk of bleeding. Aspirin lowers serum flurbiprofen concentrations.

Source: NLP:flurbiprofen

Possibility of increased bleeding due to pyridoxine interaction with anticoagulants.

Source: NLP:iron, folate

Ibuprofen interferes with the antiplatelet activity of aspirin, particularly with enteric-coated low-dose aspirin. There may be an increased risk of cardiovascular events due to this interference.

Source: NLP:ibuprofen

Ibuprofen interferes with antiplatelet activity of aspirin and increases risk of GI adverse reactions and bleeding when used together.

Source: NLP:ibuprofen and famotidine

Concomitant use associated with significantly increased incidence of GI adverse reactions and increased risk of bleeding.

Source: NLP:indomethacin

Concomitant use increases risk of bleeding and GI adverse reactions. No additional therapeutic benefit compared to ketorolac alone.

Source: NLP:ketorolac tromethamine

Concomitant use associated with significantly increased incidence of GI adverse reactions and increased risk of bleeding.

Source: NLP:diclofenac sodium gel

Increased incidence of GI adverse reactions and increased risk of bleeding; no additional therapeutic benefit over NSAID alone.

Source: NLP:mefenamic acid

Increased incidence of GI adverse reactions and increased risk of bleeding when combined with meloxicam.

Source: NLP:meloxicam

High-dose aspirin with methazolamide may cause anorexia, tachypnea, lethargy, coma, and death. Caution advised with concomitant high-dose use.

Source: NLP:methazolamide

NSAID that may increase methotrexate plasma concentrations, increasing risk of severe adverse reactions and potentially reducing clinical effectiveness.

Source: NLP:methotrexate

NSAID that may increase methotrexate plasma concentrations, increasing risk of severe adverse reactions and potentially reducing clinical effectiveness.

Source: NLP:methotrexate sodium

Concomitant use increases risk of gastrointestinal side effects. Aspirin should be used cautiously with corticosteroids in hypoprothrombinemia.

Source: NLP:methylprednisolone acetate

Naproxen interferes with antiplatelet effect of aspirin and increases risk of GI adverse reactions and bleeding when used together.

Source: NLP:naproxen

Naproxen interferes with antiplatelet effect of low-dose aspirin. Concomitant use with analgesic doses of aspirin increases GI adverse reactions and cardiovascular event risk.

Source: NLP:naproxen and esomeprazole magnesium

Lower dose naproxen interferes with antiplatelet effect of low-dose aspirin; concomitant use increases GI adverse reactions and bleeding risk.

Source: NLP:naproxen sodium

Concomitant use associated with significantly increased incidence of GI adverse reactions and increased risk of bleeding.

Source: NLP:oxaprozin

Concurrent use of aspirin with paroxetine may potentiate the risk of bleeding.

Source: NLP:paroxetine

Increased risk of bleeding with concurrent use; inform patients of increased bleeding risk.

Source: NLP:paroxetine hydrochloride hemihydrate

Concomitant use associated with significantly increased incidence of GI adverse reactions and increased risk of bleeding.

Source: NLP:piroxicam

Concomitant use increases risk of gastrointestinal side effects; use cautiously in hypoprothrombinemia.

Source: NLP:prednisolone sodium phosphate

Platelet aggregation inhibitor coadministration may increase bleeding risk. Promptly evaluate signs/symptoms of blood loss.

Source: NLP:rivaroxaban

Concurrent use may potentiate bleeding risk. Inform patients of increased bleeding risk.

Source: NLP:sertraline

Concurrent use may potentiate risk of bleeding.

Source: NLP:sertraline hydrochloride

Concomitant use of analgesic doses of aspirin with sumatriptan and naproxen sodium is not generally recommended. Aspirin interferes with hemostasis and increases bleeding risk.

Source: NLP:sumatriptan and naproxen sodium

Increased risk of upper gastrointestinal bleeding due to impaired serotonin reuptake affecting platelet hemostasis.

Source: NLP:venlafaxine hydrochloride

Bromelain may increase the risk of bleeding when combined with aspirin.

Source: NLP:vitamin c, zinc, arnica montana extract, bromelain, diosmin, rutin, citrus bioflavonoids, hesperidin methyl chalcone

Concomitant therapy with daily doses of alendronate sodium greater than 10 mg and aspirin-containing products increases incidence of upper gastrointestinal adverse events.

Source: NLP:alendronate sodium

Concomitant use of aspirin or other NSAIDs with corticosteroids requires monitoring.

Source: NLP:betamethasone acetate and betamethasone sodium phosphate

Low dose aspirin showed induction effect on CYP2C19, potentially decreasing carisoprodol exposure and increasing meprobamate exposure; full pharmacological impact unknown.

Source: NLP:carisoprodol

Concomitant use with corticosteroids increases risk of gastrointestinal side effects; use cautiously in hypoprothrombinemia.

Source: NLP:depo-medrol, lidocaine, isopropyl alcohol

Concomitant use may potentiate bleeding risk. Closely monitor for bleeding when desvenlafaxine is initiated or discontinued.

Source: NLP:desvenlafaxine

Concomitant use may potentiate risk of bleeding. Closely monitor for bleeding when desvenlafaxine is initiated or discontinued.

Source: NLP:desvenlafaxine er

Concomitant use may potentiate bleeding risk. Closely monitor for bleeding when desvenlafaxine is initiated or discontinued.

Source: NLP:desvenlafaxine succinate

Concomitant administration is not generally recommended due to potential for increased adverse effects. Aspirin reduces diflunisal protein binding and may decrease diflunisal levels.

Source: NLP:diflunisal

Decreases protein binding and inhibits metabolism of valproate, increasing valproate free fraction 4-fold. Monitoring of valproate concentrations is recommended.

Source: NLP:divalproex sodium

Concurrent use may potentiate upper gastrointestinal bleeding risk due to serotonin reuptake inhibition effects on hemostasis.

Source: NLP:duloxetine

Concurrent use may potentiate upper gastrointestinal bleeding risk due to duloxetine's effect on serotonin reuptake.

Source: NLP:duloxetine hydrochloride

Concomitant use may potentiate risk of bleeding. Patients should be informed of increased bleeding risk.

Source: NLP:escitalopram oxalate

Etodolac protein binding is reduced when co-administered with aspirin. Concomitant use is not generally recommended due to potential for increased adverse effects.

Source: NLP:etodolac

Increased ulcerogenic effect and decreased pharmacologic effect of aspirin. Risk of salicylate toxicity upon steroid discontinuation. Monitor salicylate levels and adjust dosage accordingly.

Source: NLP:fludrocortisone acetate

Concomitant use did not significantly affect pharmacokinetics/pharmacodynamics in clinical studies. Monitor patients closely for hemorrhage if co-administration is necessary.

Source: NLP:fondaparinux sodium

Combination of furosemide and acetylsalicylic acid may temporarily reduce creatinine clearance.

Source: NLP:furosemide

May interfere with platelet aggregation and induce bleeding. Use with caution in heparinized patients; dose reduction of antiplatelet agent or heparin recommended.

Source: NLP:heparin sodium

Corticosteroids may increase aspirin clearance, leading to decreased salicylate levels or increased toxicity upon corticosteroid withdrawal. Use cautiously in hypoprothrombinemia patients.

Source: NLP:hydrocortisone

Concomitant use of aspirin and corticosteroids increases risk of gastrointestinal side effects. Aspirin should be used cautiously with corticosteroids in hypoprothrombinemia.

Source: NLP:hydrocortisone sodium succinate

Caution should be exercised with concomitant use of aspirin and ibandronate as both are associated with gastrointestinal irritation.

Source: NLP:ibandronate sodium

Antiplatelet drug that may potentiate bleeding risk when used with levomilnacipran. Closely monitor for bleeding.

Source: NLP:levomilnacipran hydrochloride

Cyclooxygenase inhibitor may impact accuracy of MACRILEN diagnostic test by directly affecting pituitary growth hormone secretion. Avoid concomitant use.

Source: NLP:macimorelin acetate

Methylprednisolone may increase the clearance of chronic high dose aspirin, leading to decreased salicylate levels or increased toxicity upon withdrawal. Use cautiously in hypoprothrombinemia patients.

Source: NLP:methylprednisolone

Concomitant use with corticosteroids increases risk of gastrointestinal side effects; use cautiously in hypoprothrombinemia.

Source: NLP:methylprednisolone sodium succinate

Nabumetone's protein binding is reduced when administered with aspirin. Concomitant administration is not generally recommended due to potential increased adverse effects.

Source: NLP:nabumetone

Increases nitroglycerin maximum concentrations by up to 67% and AUC by 73%, potentially enhancing pharmacological effects. Monitor closely.

Source: NLP:nitroglycerin

May potentiate the risk of bleeding when used with drugs that interfere with hemostasis.

Source: NLP:olanzapine and fluoxetine

Concurrent use of antiplatelet agents with paroxetine may potentiate the risk of bleeding.

Source: NLP:paroxetine hydrochloride

Competes with penicillin G for renal tubular secretion, prolonging serum half-life.

Source: NLP:penicillin g

Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.

Source: NLP:penicillin g potassium

Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.

Source: NLP:penicillin g sodium

Prednisone may increase clearance of high-dose chronic aspirin, leading to decreased salicylate levels or increased toxicity upon withdrawal. Use cautiously in hypoprothrombinemia.

Source: NLP:prednisone

Regular aspirin use (≥3 days/week) was studied; upper gastrointestinal adverse experience incidence was similar between placebo and risedronate-treated patients. Monitor for GI effects.

Source: NLP:risedronate sodium

ASA may reduce the efficacy of spironolactone. May require higher maintenance doses; monitor patient closely.

Source: NLP:spironolactone

May reduce efficacy of spironolactone; higher maintenance doses may be needed.

Source: NLP:spironolactone and hydrochlorothiazide

Acetylsalicylic acid should be taken at least 1 hour before sucroferric oxyhydroxide to avoid reduced bioavailability.

Source: NLP:sucroferric oxyhydroxide

Aspirin significantly depressed plasma levels of active sulfide metabolite and increased incidence of gastrointestinal adverse experiences; combination not recommended.

Source: NLP:sulindac

Concomitant use with trazodone may increase risk of gastrointestinal bleeding. Monitor patients for bleeding risk.

Source: NLP:trazodone hydrochloride

Concomitant use increases risk of gastrointestinal side effects; use cautiously in hypoprothrombinemia.

Source: NLP:triamcinolone acetonide extended-release injectable suspension

Aspirin decreases protein binding of valproate and inhibits its metabolism, increasing valproate free fraction 4-fold and decreasing β-oxidation pathway. Monitoring of valproate concentrations is recommended.

Source: NLP:valproate sodium

Decreases protein binding and inhibits metabolism of valproate, increasing valproate free fraction 4-fold. Monitoring of valproate concentrations recommended.

Source: NLP:valproic acid

Coadministration has led to increased bleeding times greater than observed with aspirin alone in few reported cases.

Source: NLP:verapamil hydrochloride

Antiplatelet agent may potentiate risk of bleeding when used with vortioxetine. Monitor patients for increased bleeding risk.

Source: NLP:vortioxetine

Aspirin increases zafirlukast mean plasma levels by approximately 45%.

Source: NLP:zafirlukast

No drug-drug interactions have been demonstrated between argatroban and aspirin.

Source: NLP:argatroban

Limited data suggest no clinical interaction between aspirin and beta-blockers in acute myocardial infarction setting.

Source: NLP:atenolol

Used concomitantly in clinical studies without evidence of clinically significant adverse interactions.

Source: NLP:finasteride

Misoprostol does not interfere with beneficial effects of aspirin or exert clinically significant effects on absorption, blood levels, and antiplatelet effects of therapeutic doses.

Source: NLP:misoprostol

Concomitant aspirin may decrease the metabolic clearance of nicotinic acid, though clinical relevance is unclear.

Source: NLP:niacin

Administered without adverse drug interaction in limited clinical experience.

Source: NLP:prazosin hydrochloride

Peak plasma concentrations and AUC of rimantadine were reduced approximately 10% in the presence of aspirin.

Source: NLP:rimantadine hydrochloride

Terazosin has been used concomitantly with aspirin in at least 50 patients with no interactions observed.

Source: NLP:terazosin

Used concomitantly with terazosin in at least 50 patients with no interactions observed.

Source: NLP:terazosin hydrochloride

Interaction noted in WARNINGS section; specific details refer to warnings for severity information.

Source: NLP:acetazolamide extended-release