Acetylsalicylic Acid + Valproate Sodium Interaction
Moderateinteraction on record
Description
Aspirin decreases protein binding of valproate and inhibits its metabolism, increasing valproate free fraction 4-fold and decreasing β-oxidation pathway. Monitoring of valproate concentrations is recommended.
Mechanism
Displacement of protein binding and inhibition of β-oxidation metabolism
Source: NLP:valproate sodium