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Does Aficamten Interact with Fluvoxamine?

Aficamten and Fluvoxamine have a major drug interaction according to U.S. FDA drug labeling data. Strong CYP2C19 inhibitor that increases aficamten exposure, potentially increasing risk of heart failure due to systolic dysfunction. Dose reduction required. The mechanism involves cyp2c19 inhibition (strong); also weak to moderate cyp3a, weak cyp2c9, and weak cyp2d6 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Aficamten and Fluvoxamine occurs because cyp2c19 inhibition (strong); also weak to moderate cyp3a, weak cyp2c9, and weak cyp2d6 inhibition. Clinically, this means strong cyp2c19 inhibitor that increases aficamten exposure, potentially increasing risk of heart failure due to systolic dysfunction. dose reduction required. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Aficamten and your doctor is considering prescribing Fluvoxamine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Aficamten(Myqorzo)+💊 Fluvoxamine

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:aficamten

What this means in plain English

Strong CYP2C19 inhibitor that increases aficamten exposure, potentially increasing risk of heart failure due to systolic dysfunction. Dose reduction required.

What the FDA label says

"CYP2C19 inhibition (strong); also weak to moderate CYP3A, weak CYP2C9, and weak CYP2D6 inhibition"

📖 Source: NLP:aficamten

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.