Does Alprostadil Interact with Latanoprost?
Alprostadil and Latanoprost have a moderate drug interaction according to U.S. FDA drug labeling data. Combined use of two or more prostaglandins or prostaglandin analogs not recommended. More than once daily administration may decrease IOP lowering effect or cause paradoxical IOP elevations. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Alprostadil Class
- Prostaglandin Analog
- Latanoprost Class
- Prostaglandin Analog
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Alprostadil and your doctor is considering prescribing Latanoprost (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider