Does Amiodarone Interact with Phenylephrine Hydrochloride?
The phenylephrine hydrochloride injection label explicitly lists amiodarone among drugs that can oppose its blood-pressure-raising effect, and notes antagonism in the other direction as well.
Label evidence and limitations
Named-drug label evidence. This is an injection-label statement. It should not be extended to oral decongestants or nasal products, or used to infer an individual treatment decision.
Product scope: Phenylephrine hydrochloride injection for intravenous use.
Read the DailyMed label: PHENYLEPHRINE HYDROCHLORIDE INJECTION, USP 10mg PER mL 1mL VIAL
Section: 7.2 Antagonizing the Pressor Effect. Compared version 4, label date 2024-02-22. The linked label may be updated after this comparison.
This comparison uses the label identifier saved with the CDI record. The compared version may be newer than the original extraction.
AI-assisted source comparison dated 2026-10-16. This is a comparison of label text, not independent clinical review or an individual safety assessment. CDI's stored severity category is not an FDA-assigned rating. Confirm your exact medicines and formulations with your pharmacist or prescriber before changing treatment.
- Stored CDI classification
- Major
- Management
- Confirm exact products with your pharmacist
- Data Source
- Product label via NLM DailyMed
What To Tell Your Doctor or Pharmacist
If you are taking Amiodarone and your doctor is considering prescribing Phenylephrine Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider