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Does Amlodipine And Valsartan Interact with Mao Inhibitors?

Amlodipine And Valsartan and Mao Inhibitors have a major drug interaction according to U.S. FDA drug labeling data. In elderly, volume-depleted, or renally impaired patients, coadministration may result in deterioration of renal function including possible acute renal failure. May attenuate antihypertensive effect. Monitor renal function. The mechanism involves cox-2 inhibitors reduce renal perfusion and may antagonize valsartan's mechanism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Amlodipine And Valsartan Class
Angiotensin 2 Receptor Blocker
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Amlodipine And Valsartan and Mao Inhibitors occurs because cox-2 inhibitors reduce renal perfusion and may antagonize valsartan's mechanism. Clinically, this means in elderly, volume-depleted, or renally impaired patients, coadministration may result in deterioration of renal function including possible acute renal failure. may attenuate antihypertensive effect. monitor renal function. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Amlodipine And Valsartan and your doctor is considering prescribing Mao Inhibitors (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Amlodipine And Valsartan(Amlodipine And Valsartan)+💊 Mao Inhibitors

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Angiotensin 2 Receptor Blocker
Drug B class
—
Source
NLP:amlodipine and valsartan

What this means in plain English

In elderly, volume-depleted, or renally impaired patients, coadministration may result in deterioration of renal function including possible acute renal failure. May attenuate antihypertensive effect. Monitor renal function.

What the FDA label says

"COX-2 inhibitors reduce renal perfusion and may antagonize valsartan's mechanism"

📖 Source: NLP:amlodipine and valsartan

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.