Does Mao Inhibitors Interact with Aliskiren Hemifumarate?
CDI records a contraindicated classification for Mao Inhibitors and Aliskiren Hemifumarate. The stored summary is: Concomitant use with ACE inhibitors in diabetic patients is contraindicated. In non-diabetics, generally avoid combined use, especially with CrCl <60 mL/min, due to increased risk of hypotension, hyperkalemia, and acute renal failure. The mechanism involves dual blockade of the renin-angiotensin-aldosterone system (raas). Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Dual blockade of the renin-angiotensin-aldosterone system (RAAS)
What To Tell Your Doctor or Pharmacist
If you are taking Mao Inhibitors and your doctor is considering prescribing Aliskiren Hemifumarate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider