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Does Amoxicillin Oral Susp Interact with Allopurinol?

Amoxicillin Oral Susp and Allopurinol have a moderate drug interaction according to U.S. FDA drug labeling data. Concurrent use increases the incidence of rashes compared to Amoxicillin alone. The mechanism is unclear. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Allopurinol Class
Xanthine Oxidase Inhibitor
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Amoxicillin Oral Susp and your doctor is considering prescribing Allopurinol (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Amoxicillin Oral Susp(Amoxil)+💊 Allopurinol(Zyloprim)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Xanthine Oxidase Inhibitor
Source
NLP:amoxicillin oral susp

What this means in plain English

Concurrent use increases the incidence of rashes compared to Amoxicillin alone. The mechanism is unclear.

About Amoxicillin Oral Susp and Allopurinol

Allopurinol is a Xanthine Oxidase Inhibitor. You may recognize them by the brand names Amoxil and Zyloprim. Both medications are taken by mouth. Allopurinol additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.