Does Angiotensin Ii Interact with Diflunisal?
CDI records a moderate classification for Angiotensin Ii and Diflunisal. The stored summary is: NSAIDs may diminish the antihypertensive effect of angiotensin II antagonists. Co-administration may result in further deterioration of renal function, including possible acute renal failure in patients with compromised renal function. The mechanism involves nsaids may diminish antihypertensive effect. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Angiotensin Ii Class
- Vasoconstrictor
- Diflunisal Class
- Nonsteroidal Anti-inflammatory Drug
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
NSAIDs may diminish antihypertensive effect
What To Tell Your Doctor or Pharmacist
If you are taking Angiotensin Ii and your doctor is considering prescribing Diflunisal (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider