Does Cyclosporine Interact with Diflunisal?
CDI records a major classification for Cyclosporine and Diflunisal. The stored summary is: NSAIDs concomitantly administered with cyclosporine have been associated with increased cyclosporine-induced toxicity. Renal function should be carefully monitored. The mechanism involves possibly due to decreased synthesis of renal prostacyclin. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Cyclosporine Class
- Calcineurin Inhibitor Immunosuppressant
- Diflunisal Class
- Nonsteroidal Anti-inflammatory Drug
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Possibly due to decreased synthesis of renal prostacyclin
What To Tell Your Doctor or Pharmacist
If you are taking Cyclosporine and your doctor is considering prescribing Diflunisal (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider