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Does Aspirin Interact with Alendronate Sodium And Cholecalciferol?

Aspirin and Alendronate Sodium And Cholecalciferol have a moderate drug interaction according to U.S. FDA drug labeling data. Concomitant therapy with daily doses of alendronate greater than 10 mg and aspirin-containing products increased incidence of upper gastrointestinal adverse events. The mechanism involves gastrointestinal irritation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Aspirin Class
Nonsteroidal Anti-inflammatory Drug [EPC]
Alendronate Sodium And Cholecalciferol Class
Vitamin D
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Aspirin and Alendronate Sodium And Cholecalciferol occurs because gastrointestinal irritation. Clinically, this means concomitant therapy with daily doses of alendronate greater than 10 mg and aspirin-containing products increased incidence of upper gastrointestinal adverse events. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Aspirin and your doctor is considering prescribing Alendronate Sodium And Cholecalciferol (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Aspirin(Acetylsalicylic Acid)+💊 Alendronate Sodium And Cholecalciferol(Fosamax Plus D)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
Nonsteroidal Anti-inflammatory Drug [EPC]
Drug B class
Vitamin D
Source
NLP:alendronate sodium and cholecalciferol

What this means in plain English

Concomitant therapy with daily doses of alendronate greater than 10 mg and aspirin-containing products increased incidence of upper gastrointestinal adverse events.

About Aspirin and Alendronate Sodium And Cholecalciferol

Aspirin is a Nonsteroidal Anti-inflammatory Drug, while Alendronate Sodium And Cholecalciferol is a Vitamin D. Aspirin is also sold under the brand name Ecotrin. Both medications are taken by mouth.

What the FDA label says

"Gastrointestinal irritation"

📖 Source: NLP:alendronate sodium and cholecalciferol

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.