Does Aspirin Interact with Dichlorphenamide?
CDI records a contraindicated classification for Aspirin and Dichlorphenamide. The stored summary is: High-dose aspirin with dichlorphenamide is contraindicated due to risk of anorexia, tachypnea, lethargy, and coma. Low-dose aspirin requires careful monitoring. The mechanism involves dichlorphenamide causes metabolic acidosis, increasing salicylate toxicity risk. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Aspirin Class
- Nonsteroidal Anti-inflammatory Drug [EPC]
- Dichlorphenamide Class
- Carbonic Anhydrase Inhibitor
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Dichlorphenamide causes metabolic acidosis, increasing salicylate toxicity risk
What To Tell Your Doctor or Pharmacist
If you are taking Aspirin and your doctor is considering prescribing Dichlorphenamide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider