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Does Aspirin Interact with Spironolactone?

Aspirin and Spironolactone have a moderate drug interaction according to U.S. FDA drug labeling data. ASA may reduce the efficacy of spironolactone. May require higher maintenance doses; monitor patient closely. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Aspirin Class
Nonsteroidal Anti-inflammatory Drug [EPC]
Spironolactone Class
Aldosterone Antagonist
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Aspirin and your doctor is considering prescribing Spironolactone (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Aspirin(Acetylsalicylic Acid)+💊 Spironolactone(Aldactone)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
Nonsteroidal Anti-inflammatory Drug [EPC]
Drug B class
Aldosterone Antagonist
Source
NLP:spironolactone

What this means in plain English

ASA may reduce the efficacy of spironolactone. May require higher maintenance doses; monitor patient closely.

About Aspirin and Spironolactone

Aspirin is a Nonsteroidal Anti-inflammatory Drug, while Spironolactone is an Aldosterone Antagonist. You may recognize them by the brand names Ecotrin and Aldactone. Both medications are taken by mouth. Spironolactone additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.