Does Aspirin Interact with Valproate Sodium?
CDI records a moderate classification for Aspirin and Valproate Sodium. The stored summary is: Aspirin decreases protein binding of valproate and inhibits its metabolism, increasing valproate free fraction 4-fold and decreasing β-oxidation pathway. Monitoring of valproate concentrations is recommended. The mechanism involves displacement of protein binding and inhibition of β-oxidation metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Aspirin Class
- Nonsteroidal Anti-inflammatory Drug [EPC]
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Displacement of protein binding and inhibition of β-oxidation metabolism
What To Tell Your Doctor or Pharmacist
If you are taking Aspirin and your doctor is considering prescribing Valproate Sodium (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider