Does Atropine Sulfate Injection Interact with Mexiletine?
CDI records a moderate classification for Atropine Sulfate Injection and Mexiletine. The stored summary is: Atropine Sulfate Injection decreased the rate of mexiletine absorption without altering relative oral bioavailability. This delay was reversed by combination of atropine and intravenous metoclopramide. The mechanism involves decreased absorption rate. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Decreased absorption rate
What To Tell Your Doctor or Pharmacist
If you are taking Atropine Sulfate Injection and your doctor is considering prescribing Mexiletine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider