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Does Azilsartan Kamedoxomil Interact with Mao Inhibitors?

Azilsartan Kamedoxomil and Mao Inhibitors have a major drug interaction according to U.S. FDA drug labeling data. COX-2 inhibitors increase risk of renal dysfunction and acute renal failure when combined with azilsartan. Effects usually reversible. May attenuate antihypertensive effect. The mechanism involves deterioration of renal function similar to nsaids. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Azilsartan Kamedoxomil Class
Thiazide-like Diuretic
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Azilsartan Kamedoxomil and Mao Inhibitors occurs because deterioration of renal function similar to nsaids. Clinically, this means cox-2 inhibitors increase risk of renal dysfunction and acute renal failure when combined with azilsartan. effects usually reversible. may attenuate antihypertensive effect. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Azilsartan Kamedoxomil and your doctor is considering prescribing Mao Inhibitors (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Azilsartan Kamedoxomil(Azilsartan Medoxomil)+💊 Mao Inhibitors

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Thiazide-like Diuretic
Drug B class
—
Source
NLP:azilsartan kamedoxomil and chlorthalidone

What this means in plain English

COX-2 inhibitors increase risk of renal dysfunction and acute renal failure when combined with azilsartan. Effects usually reversible. May attenuate antihypertensive effect.

What the FDA label says

"Deterioration of renal function similar to NSAIDs"

📖 Source: NLP:azilsartan kamedoxomil and chlorthalidone

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.