Does Bempedoic Acid Interact with Pravastatin?
Bempedoic Acid and Pravastatin have a major drug interaction according to U.S. FDA drug labeling data. Pravastatin Clinical Impact: Concomitant use of NEXLETOL with pravastatin causes an increase in pravastatin concentration and may increase the risk of pravastatin-related myopathy [see Clinical Pharmacology (12.3) ] . Intervention: Avoid concomitant use of NEXLETOL with pravastatin greater than 40 mg. ( 7 ) Pravastatin: Avoid concomitant use of NEXLETOL with pravastatin greater than 40 mg. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Bempedoic Acid Class
- Adenosine Triphosphate-Citrate Lyase Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Bempedoic Acid and your doctor is considering prescribing Pravastatin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider