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Does Benznidazole Interact with Disulfiram?

Benznidazole and Disulfiram have a contraindicated drug interaction according to U.S. FDA drug labeling data. Psychotic reactions reported with concurrent use of disulfiram and nitroimidazole agents. Benznidazole should not be given to patients who have taken disulfiram within the last two weeks. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Disulfiram Class
Aldehyde Dehydrogenase Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Benznidazole and your doctor is considering prescribing Disulfiram (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Benznidazole(Benznidazole)+💊 Disulfiram(Antabuse)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Aldehyde Dehydrogenase Inhibitor
Source
NLP:benznidazole

What this means in plain English

Psychotic reactions reported with concurrent use of disulfiram and nitroimidazole agents. Benznidazole should not be given to patients who have taken disulfiram within the last two weeks.

About Benznidazole and Disulfiram

Disulfiram is an Aldehyde Dehydrogenase Inhibitor. Disulfiram is also sold under the brand name Antabuse. Both medications are taken by mouth. Disulfiram additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.