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Does Bismuth Subcitrate Potassium Metronidazole And Tetracycline Interact with Disulfiram?

Bismuth Subcitrate Potassium Metronidazole And Tetracycline and Disulfiram have a contraindicated drug interaction according to U.S. FDA drug labeling data. Psychotic reactions can occur; do not take concurrently or within the last 2 weeks of disulfiram. The mechanism involves interaction between metronidazole component and disulfiram. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Bismuth Subcitrate Potassium Metronidazole And Tetracycline Class
Nitroimidazole Antimicrobial
Disulfiram Class
Aldehyde Dehydrogenase Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Bismuth Subcitrate Potassium Metronidazole And Tetracycline and Disulfiram occurs because interaction between metronidazole component and disulfiram. Clinically, this means psychotic reactions can occur; do not take concurrently or within the last 2 weeks of disulfiram. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Bismuth Subcitrate Potassium Metronidazole And Tetracycline and your doctor is considering prescribing Disulfiram (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Bismuth Subcitrate Potassium Metronidazole And Tetracycline (Pylera)+💊 Disulfiram(Antabuse)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Nitroimidazole Antimicrobial
Drug B class
Aldehyde Dehydrogenase Inhibitor
Source
NLP:bismuth subcitrate potassium, metronidazole and tetracycline hydrochloride

What this means in plain English

Psychotic reactions can occur; do not take concurrently or within the last 2 weeks of disulfiram.

About Bismuth Subcitrate Potassium Metronidazole And Tetracycline and Disulfiram

Bismuth Subcitrate Potassium Metronidazole And Tetracycline is a Nitroimidazole Antimicrobial, while Disulfiram is an Aldehyde Dehydrogenase Inhibitor. You may recognize them by the brand names Pylera and Antabuse. Both medications are taken by mouth. Both Bismuth Subcitrate Potassium Metronidazole And Tetracycline and Disulfiram carry an FDA boxed warning — the agency's most serious safety designation.

What the FDA label says

"Interaction between metronidazole component and disulfiram"

📖 Source: NLP:bismuth subcitrate potassium, metronidazole and tetracycline hydrochloride

Recent research & FDA safety updates

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.